Compared to the Māori and NZ European groups, the Pacific Island and Indian participants spoke of losing culture, missing extended family support, and not having access to culturally appropriate nutrition education or social support and services.
Scientific Nutrition Research Paper
The influence of alcohol consumption on the association of protein intake with muscle mass was assessed using data from the Korean Genome and Epidemiology Study.IRPs are considered the master regulators of intracellular iron homeostasis because they coordinate the expression of iron storage (ferritin) and iron uptake (transferrin receptor) genes.In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type.The Asia Pacific Nutrigenomics Nutrigenetics Organisation (APNNO), Italian Society for Pediatric Nutrition and Gastroenterology (SIGENP), Nutrition Society of New Zealand (NSNZ), The Nutrition Society of Australia (NSA), International Chair for Advanced Studies on Hydration (CIEAH) and more societies are affiliated with Māori, Pacific, Indian, and New Zealand European pre-school children’s caregivers’ views on determinants of childhood obesity are needed to inform strategies that will reduce disparities in prevalence.Nineteen focus groups were conducted to explore the relative influence of factors contributing to body weight [...] Read more.The primary objective of this work was to determine how TP53 mutation status influences the molecular control of iron homeostasis.The effect of TP53 mutation type on cellular iron homeostasis was examined using cell lines with inducible versions of either wild-type TP53 or a representative mutated TP53 gene from exemplary “hotspot” mutations in the DNA binding domain (R248, R273, and R175) as well as H193Y.TP53 null H1299 cells (H1299) were transfected with either a tetracycline inducible wild-type (WT) TP53 or a representative contact (R237H or R248Q) or conformational (R175H or H193Y) mutant TP53.() heme oxygenase 1 (HMOX1) in TP53 null H1299 cells (H1299) or H1299 cells transfected with wild-type (WT) TP53, or the indicated mutant TP53. Superscripts (a,b,c) denote statistical significance between mutation types, ) heme oxygenase 1 (HMOX1) in TP53 null H1299 cells (H1299) or H1299 cells transfected with wild-type (WT) TP53, or the indicated mutant TP53 following treatment with DMSO (control) or 40 µM hemin for 48 h.However, all mutation types exhibited robust changes in ferritin and transferrin receptor protein expression in response to iron loading and iron chelation, respectively.These findings suggest a novel, IRP-independent mode of iron regulation in cells expressing distinct TP53 mutations.
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