Magnetic Nanoparticles Thesis

Magnetic Nanoparticles Thesis-53
By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.With the work in this thesis we have established the feasibility of using ex vivo magnetic SLNM to improve staging accuracy of colorectal cancer patients, in routine clinical practice.

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The sentinel lymph nodes (SLNs) receive direct lymphatic drainage from the tumour area, and are therefore most likely the first site of metastasis, if present.A commercially available magnetometer and magnetic tracer were used for SLN identification in patients suffering from colorectal cancer to evaluate the feasibility of the technique.Patient, animal and phantom studies were performed to optimize the use of the SLNB technique with magnetic nanoparticles in breast cancer patients.TY - THEST1 - Sentinel lymph node identification with magnetic nanoparticles AU - Pouw, Joost Jacob PY - 2016/1/29Y1 - 2016/1/29N2 - Most solid malignancies have a tendency to spread through the lymphatic system to locoregional lymph nodes.AB - Most solid malignancies have a tendency to spread through the lymphatic system to locoregional lymph nodes.The experimental findings are compared with calculated magnetic anisotropy contributions of the three different types of deposited nanoparticles (NPs).It was found that despite their different atomic structure, the body-centered cubic (bcc) iron and face-centered cubic (fcc) cobalt nanoparticles have a similar behavior and can exist in a state which demonstrates an unexpected ferromagnetic (FM) behavior with sizes down to 8 nm at room temperature (RT), while nickel particles only exhibit the expected superparamagnetic (SPM) behavior.Throughout this thesis, solution-based synthesis methods are used to fabricate MNPs with a variety of shapes, from spheres and cubes to wires and octapods.Chapter 3 assesses the role of polyol solvent in autoclave-based magnetite NP synthesis.Detailed calculations of all magnetic anisotropy contributions for different sizes and types of particles indicate that the reported high anisotropy state can be associated with a meta-stable structural state due to the presence of local defects within the NPs, independent of the particle atomic structure and size.These observations shed new light on the mechanisms which establish the size-dependent evolution of magnetic properties at the nanoscale.


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